LymphedemaV1, Main, Exploration, bibRecord, 000F64

Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency.

Identifieur interne : 000F64 ( Main/Exploration ); précédent : 000F63; suivant : 000F65

Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency.

Auteurs : Patrick Mucka [États-Unis] ; Nicholas Levonyak [États-Unis] ; Elena Geretti [États-Unis] ; Bernadette M M. Zwaans [États-Unis] ; Xiaoran Li [États-Unis] ; Irit Adini [États-Unis] ; Michael Klagsbrun [États-Unis] ; Rosalyn M. Adam [États-Unis] ; Diane R. Bielenberg [États-Unis]

Source :

The American journal of pathology [ 1525-2191 ] ; 2016.

RBID : pubmed:27751443

Descripteurs français

English descriptors

KwdEn :
- Animals, Blood Vessels (physiopathology), Capillary Permeability, Female, Humans, Inflammation (genetics), Inflammation (physiopathology), Lymphatic Vessels (physiopathology), Lymphedema (genetics), Lymphedema (physiopathology), Membrane Proteins (genetics), Membrane Proteins (metabolism), Mice, Mice, Inbred BALB C, Nerve Tissue Proteins (genetics), Nerve Tissue Proteins (metabolism), Neuropilin-2 (deficiency), Neuropilin-2 (genetics), Neuropilin-2 (metabolism), Specific Pathogen-Free Organisms, Vascular Endothelial Growth Factor A (genetics), Vascular Endothelial Growth Factor A (metabolism).
MESH :
- chemical , deficiency : Neuropilin-2.
- chemical , genetics : Membrane Proteins, Nerve Tissue Proteins, Neuropilin-2, Vascular Endothelial Growth Factor A.
- genetics : Inflammation, Lymphedema.
- chemical , metabolism : Membrane Proteins, Nerve Tissue Proteins, Neuropilin-2, Vascular Endothelial Growth Factor A.
- physiopathology : Blood Vessels, Inflammation, Lymphatic Vessels, Lymphedema.
- Animals, Capillary Permeability, Female, Humans, Mice, Mice, Inbred BALB C, Specific Pathogen-Free Organisms.

Abstract

The vasculature influences the progression and resolution of tissue inflammation. Capillaries express vascular endothelial growth factor (VEGF) receptors, including neuropilins (NRPs), which regulate interstitial fluid flow. NRP2, a receptor of VEGFA and semaphorin (SEMA) 3F ligands, is expressed in the vascular and lymphatic endothelia. Previous studies have demonstrated that blocking VEGF receptor 2 attenuates VEGFA-induced vascular permeability. The inhibition of NRP2 was hypothesized to decrease vascular permeability as well. Unexpectedly, massive tissue swelling and edema were observed in Nrp2(-/-) mice compared with wild-type littermates after delayed-type hypersensitivity reactions. Vascular permeability was twofold greater in inflamed blood vessels in Nrp2-deficient mice compared to those in Nrp2-intact littermates. The addition of exogenous SEMA3F protein inhibited vascular permeability in Balb/cJ mice, suggesting that the loss of endogenous Sema3F activity in the Nrp2-deficient mice was responsible for the enhanced vessel leakage. Functional lymphatic capillaries are necessary for draining excess fluid after inflammation; however, Nrp2-mutant mice lacked superficial lymphatic capillaries, leading to 2.5-fold greater fluid retention and severe lymphedema after inflammation. In conclusion, Nrp2 deficiency increased blood vessel permeability and decreased lymphatic vessel drainage during inflammation, highlighting the importance of the NRP2/SEMA3F pathway in the modulation of tissue swelling and resolution of postinflammatory edema.

DOI: 10.1016/j.ajpath.2016.07.022
PubMed: 27751443

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency.</title>
<author><name sortKey="Mucka, Patrick" sort="Mucka, Patrick" uniqKey="Mucka P" first="Patrick" last="Mucka">Patrick Mucka</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Levonyak, Nicholas" sort="Levonyak, Nicholas" uniqKey="Levonyak N" first="Nicholas" last="Levonyak">Nicholas Levonyak</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Geretti, Elena" sort="Geretti, Elena" uniqKey="Geretti E" first="Elena" last="Geretti">Elena Geretti</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zwaans, Bernadette M M" sort="Zwaans, Bernadette M M" uniqKey="Zwaans B" first="Bernadette M M" last="Zwaans">Bernadette M M. Zwaans</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Li, Xiaoran" sort="Li, Xiaoran" uniqKey="Li X" first="Xiaoran" last="Li">Xiaoran Li</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Adini, Irit" sort="Adini, Irit" uniqKey="Adini I" first="Irit" last="Adini">Irit Adini</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klagsbrun, Michael" sort="Klagsbrun, Michael" uniqKey="Klagsbrun M" first="Michael" last="Klagsbrun">Michael Klagsbrun</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Adam, Rosalyn M" sort="Adam, Rosalyn M" uniqKey="Adam R" first="Rosalyn M" last="Adam">Rosalyn M. Adam</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Harvard Medical School, Boston, Massachusetts; Urological Diseases Research Center, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Surgery, Harvard Medical School, Boston, Massachusetts; Urological Diseases Research Center, Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bielenberg, Diane R" sort="Bielenberg, Diane R" uniqKey="Bielenberg D" first="Diane R" last="Bielenberg">Diane R. Bielenberg</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts. Electronic address: diane.bielenberg@childrens.harvard.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27751443</idno>
<idno type="pmid">27751443</idno>
<idno type="doi">10.1016/j.ajpath.2016.07.022</idno>
<idno type="wicri:Area/PubMed/Corpus">000540</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000540</idno>
<idno type="wicri:Area/PubMed/Curation">000540</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000540</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000540</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000540</idno>
<idno type="wicri:Area/Ncbi/Merge">008914</idno>
<idno type="wicri:Area/Ncbi/Curation">008914</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">008914</idno>
<idno type="wicri:Area/Main/Merge">000F66</idno>
<idno type="wicri:Area/Main/Curation">000F64</idno>
<idno type="wicri:Area/Main/Exploration">000F64</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency.</title>
<author><name sortKey="Mucka, Patrick" sort="Mucka, Patrick" uniqKey="Mucka P" first="Patrick" last="Mucka">Patrick Mucka</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Levonyak, Nicholas" sort="Levonyak, Nicholas" uniqKey="Levonyak N" first="Nicholas" last="Levonyak">Nicholas Levonyak</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Geretti, Elena" sort="Geretti, Elena" uniqKey="Geretti E" first="Elena" last="Geretti">Elena Geretti</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zwaans, Bernadette M M" sort="Zwaans, Bernadette M M" uniqKey="Zwaans B" first="Bernadette M M" last="Zwaans">Bernadette M M. Zwaans</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Li, Xiaoran" sort="Li, Xiaoran" uniqKey="Li X" first="Xiaoran" last="Li">Xiaoran Li</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Adini, Irit" sort="Adini, Irit" uniqKey="Adini I" first="Irit" last="Adini">Irit Adini</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klagsbrun, Michael" sort="Klagsbrun, Michael" uniqKey="Klagsbrun M" first="Michael" last="Klagsbrun">Michael Klagsbrun</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Adam, Rosalyn M" sort="Adam, Rosalyn M" uniqKey="Adam R" first="Rosalyn M" last="Adam">Rosalyn M. Adam</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Harvard Medical School, Boston, Massachusetts; Urological Diseases Research Center, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Surgery, Harvard Medical School, Boston, Massachusetts; Urological Diseases Research Center, Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bielenberg, Diane R" sort="Bielenberg, Diane R" uniqKey="Bielenberg D" first="Diane R" last="Bielenberg">Diane R. Bielenberg</name>
<affiliation wicri:level="2"><nlm:affiliation>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts. Electronic address: diane.bielenberg@childrens.harvard.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The American journal of pathology</title>
<idno type="eISSN">1525-2191</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Blood Vessels (physiopathology)</term>
<term>Capillary Permeability</term>
<term>Female</term>
<term>Humans</term>
<term>Inflammation (genetics)</term>
<term>Inflammation (physiopathology)</term>
<term>Lymphatic Vessels (physiopathology)</term>
<term>Lymphedema (genetics)</term>
<term>Lymphedema (physiopathology)</term>
<term>Membrane Proteins (genetics)</term>
<term>Membrane Proteins (metabolism)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Nerve Tissue Proteins (metabolism)</term>
<term>Neuropilin-2 (deficiency)</term>
<term>Neuropilin-2 (genetics)</term>
<term>Neuropilin-2 (metabolism)</term>
<term>Specific Pathogen-Free Organisms</term>
<term>Vascular Endothelial Growth Factor A (genetics)</term>
<term>Vascular Endothelial Growth Factor A (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Facteur de croissance endothéliale vasculaire de type A (génétique)</term>
<term>Facteur de croissance endothéliale vasculaire de type A (métabolisme)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Inflammation (génétique)</term>
<term>Inflammation (physiopathologie)</term>
<term>Lymphoedème (génétique)</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Neuropiline 2 (déficit)</term>
<term>Neuropiline 2 (génétique)</term>
<term>Neuropiline 2 (métabolisme)</term>
<term>Organismes exempts d'organismes pathogènes spécifiques</term>
<term>Perméabilité capillaire</term>
<term>Protéines de tissu nerveux (génétique)</term>
<term>Protéines de tissu nerveux (métabolisme)</term>
<term>Protéines membranaires (génétique)</term>
<term>Protéines membranaires (métabolisme)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Vaisseaux lymphatiques (physiopathologie)</term>
<term>Vaisseaux sanguins (physiopathologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Neuropilin-2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Proteins</term>
<term>Nerve Tissue Proteins</term>
<term>Neuropilin-2</term>
<term>Vascular Endothelial Growth Factor A</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Neuropiline 2</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Inflammation</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term>
<term>Inflammation</term>
<term>Lymphoedème</term>
<term>Neuropiline 2</term>
<term>Protéines de tissu nerveux</term>
<term>Protéines membranaires</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Proteins</term>
<term>Nerve Tissue Proteins</term>
<term>Neuropilin-2</term>
<term>Vascular Endothelial Growth Factor A</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term>
<term>Neuropiline 2</term>
<term>Protéines de tissu nerveux</term>
<term>Protéines membranaires</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Inflammation</term>
<term>Lymphoedème</term>
<term>Vaisseaux lymphatiques</term>
<term>Vaisseaux sanguins</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Blood Vessels</term>
<term>Inflammation</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Capillary Permeability</term>
<term>Female</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Specific Pathogen-Free Organisms</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Organismes exempts d'organismes pathogènes spécifiques</term>
<term>Perméabilité capillaire</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The vasculature influences the progression and resolution of tissue inflammation. Capillaries express vascular endothelial growth factor (VEGF) receptors, including neuropilins (NRPs), which regulate interstitial fluid flow. NRP2, a receptor of VEGFA and semaphorin (SEMA) 3F ligands, is expressed in the vascular and lymphatic endothelia. Previous studies have demonstrated that blocking VEGF receptor 2 attenuates VEGFA-induced vascular permeability. The inhibition of NRP2 was hypothesized to decrease vascular permeability as well. Unexpectedly, massive tissue swelling and edema were observed in Nrp2(-/-) mice compared with wild-type littermates after delayed-type hypersensitivity reactions. Vascular permeability was twofold greater in inflamed blood vessels in Nrp2-deficient mice compared to those in Nrp2-intact littermates. The addition of exogenous SEMA3F protein inhibited vascular permeability in Balb/cJ mice, suggesting that the loss of endogenous Sema3F activity in the Nrp2-deficient mice was responsible for the enhanced vessel leakage. Functional lymphatic capillaries are necessary for draining excess fluid after inflammation; however, Nrp2-mutant mice lacked superficial lymphatic capillaries, leading to 2.5-fold greater fluid retention and severe lymphedema after inflammation. In conclusion, Nrp2 deficiency increased blood vessel permeability and decreased lymphatic vessel drainage during inflammation, highlighting the importance of the NRP2/SEMA3F pathway in the modulation of tissue swelling and resolution of postinflammatory edema.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Mucka, Patrick" sort="Mucka, Patrick" uniqKey="Mucka P" first="Patrick" last="Mucka">Patrick Mucka</name>
</region>
<name sortKey="Adam, Rosalyn M" sort="Adam, Rosalyn M" uniqKey="Adam R" first="Rosalyn M" last="Adam">Rosalyn M. Adam</name>
<name sortKey="Adini, Irit" sort="Adini, Irit" uniqKey="Adini I" first="Irit" last="Adini">Irit Adini</name>
<name sortKey="Bielenberg, Diane R" sort="Bielenberg, Diane R" uniqKey="Bielenberg D" first="Diane R" last="Bielenberg">Diane R. Bielenberg</name>
<name sortKey="Geretti, Elena" sort="Geretti, Elena" uniqKey="Geretti E" first="Elena" last="Geretti">Elena Geretti</name>
<name sortKey="Klagsbrun, Michael" sort="Klagsbrun, Michael" uniqKey="Klagsbrun M" first="Michael" last="Klagsbrun">Michael Klagsbrun</name>
<name sortKey="Levonyak, Nicholas" sort="Levonyak, Nicholas" uniqKey="Levonyak N" first="Nicholas" last="Levonyak">Nicholas Levonyak</name>
<name sortKey="Li, Xiaoran" sort="Li, Xiaoran" uniqKey="Li X" first="Xiaoran" last="Li">Xiaoran Li</name>
<name sortKey="Zwaans, Bernadette M M" sort="Zwaans, Bernadette M M" uniqKey="Zwaans B" first="Bernadette M M" last="Zwaans">Bernadette M M. Zwaans</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F64 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F64 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:27751443
   |texte=   Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27751443" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency.

Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.